All but one of the sheriff's party are killed that night by the powerful grand witch Muriel, who sends one man back to the town tavern as a warning to the locals. Berringer hires trackers for the same mission in the hopes of disgracing the mayor and cementing his power. Mayor Englemann tells the crowd that he has hired the siblings to rescue several children presumed abducted by witches. Now adult, witch hunters Hansel and Gretel arrive in the town of Augsburg and immediately prevent Sheriff Berringer from executing a beautiful young woman named Mina for witchcraft.
He needs a shot of a insulin potion every few hours or he will get sick and die. The pair find that they are somehow immune to spells and curses, but the incident in the gingerbread house has left Hansel forever changed with a form of supernatural diabetes. In the fifteen years that follow, Hansel and Gretel become famed witch hunters, slaying hundreds of witches. The siblings outsmart her and incinerate her in the fire of the oven.
The witch forces Hansel to continuously eat candy to fatten him up, and enslaves Gretel by ordering her to prepare the oven. Abandoned by their father deep in a forest, young Hansel and Gretel enter a gingerbread house and are captured by a cannibalistic witch.